A Major Advancement in the Fight Against Resistant Fat

SOPHIA ANTIPOLIS, France, July 7, 2011 -

Until now, there has been no scientifically
proven way to eliminate fat that was resistant to diet and
exercise.

“Impact of a mechano stimulation LPG ® on gene expression
profile and lipid mobilisation in female gluteofemoral adipose
tissue*”

*Study published in the journal Obesity
Facts (April 2011, vol. 4, pp. 121-129)

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Bad dietary habits and modern sedentary lifestyles have
converged to create a worldwide epidemic that is
constantly increasing: obesity (BMI > 30).

One billion adults around the world
and twenty-two million children under the age of 5 are
overweight.

Faced with this problem, LPG wanted to study the effect
of mechano stimulation LPG ® on fat cells to obtain
proven results of the impact of Cellu M6® on
localised areas of fat.

Overview of the Study:

Report: Excess fatty volume is particularly resistant to
diet and exercise because fat cells are less able to eliminate
fat (they have reduced lipolytic capabilities). This is due to
the fact that their surface contains more alpha (anti-lipolysis)
receptors than beta (pro-lipolysis) receptors, which do not respond
well to hormone stimulation.

Methods: Prof. Max Lafontan (research director
emeritus at INSERM Toulouse) used two highly sophisticated
techniques:

Twelve before-and-after observations of twelve gynecoid,
overweight (BMI > 25) females using new generation Cellu
M6^®:

• The microdialysis (implantation of a double
  probe) allowed researchers to study adipose tissue and lipolysis
  directly.

Only two research centres in the world use this
technique: Dr Lafontan in Toulouse and Dr Arner in Sweden.

• The genomic (DNA chips) allowed researchers to directly
  study variations of gene expression after biopsy of adipose
  tissue.

Results
ExceedingExpectations:

The study underscored the considerable functional impact of
mechano stimulation LPG® on adipose tissue. Lipolytic response is
increased by 70% after 12 sessions with Cellu
M6^®.

The genomic study shows that there is no change in the
fat cells.

First Worldwide Advance

Where diet and exercise have failed…

Mechano stimulation  LPG® is the missing link to
eliminate localised fat [editor's note: in addition to a healthy
diet and regular exercise].

This important discovery is a promising first step in treating
resistant adipose deposits.

Anne Zuccarelli +33(0)-1-53-32-28-00
anne.zuccarelli@vianova-rp.com

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