PharmaMar Commences Clinical Trial in U.S. with New Antitumor Product, PM060184

PM060184 is a new marine-derived compound which has shown strong antitumor activity in preclinical models and a favorable safety profile in animal toxicology studies

MADRID, February 8, 2011 - PharmaMar SA (Grupo Zeltia, ZEL.MC) has announced the commencement of a
Phase I clinical trial with PM060184 for patients with solid tumors. PM060184
is a marine-derived synthetically-produced compound which has shown strong in
vitro and in vivo antitumor activity and a favorable safety profile in
preclinical toxicology studies. PM060184 is PharmaMar's sixth compound under
clinical development.

The trials will be performed in hospitals in the U.S., and also in France
and Spain. The primary endpoints of this Phase I trial are to identify the
dose limiting toxicity (DLT), the maximum tolerated dose (MTD) and the
recommended dose (RD) of PM060184.

Additionally, the drug's pharmacokinetic profile will be defined and a
preliminary evaluation of its antitumor activity in patients will be
performed.

About PharmaMar

PharmaMar is Grupo Zeltia's biotechnology subsidiary; it is a world
leader in discovering, developing and selling marine-based drugs to treat
cancer. Yondelis(R) is Spain's first antitumor drug. Yondelis(R) is currently
approved for STS in 33 countries outside the EEA, and in 10 of those
countries for platinum-sensitive ROC as well (including Brazil and Canada).
Yondelis(R) is approved for STS and platinum-sensitive ROC in all 30
countries of the EEA; in Switzerland it is approved for STS. Phase II
clinical trials with Yondelis(R) are also under way on prostate, breast, lung
and paediatric cancers. PharmaMar has five other compounds in clinical
development: Aplidin(R), Irvalec(R), Zalypsis(R), PM01183 and PM060184.
PharmaMar also has a rich pipeline of pre-clinical candidates and a major R&D
programme.

About Zeltia

Zeltia S.A. is a world-leading biopharmaceutical company specialised in
the development of marine-based drugs for use in oncology and central nervous
system illnesses. Grupo Zeltia consists mainly of the following companies:
PharmaMar, the world-leading biotechnology company in advancing cancer care
through the discovery and development of innovative marine-derived medicines;
Noscira, a biotech firm focused on discovering and developing new drugs
against Alzheimer's disease and other neurodegenerative diseases of the
central nervous system; Genomica, Spain's leading molecular diagnostics
company; Sylentis, dedicated to researching therapeutic applications of gene
silencing (RNAi); and a chemical division comprising Zelnova and Xylazel, two
highly profitable companies that are leaders in their respective market
segments.

Important note

PharmaMar, which is headquartered in Madrid (Spain), is a subsidiary of
Grupo Zeltia (Spanish stock exchange: ZEL), which has been listed on the
Spanish Stock Exchange since 1963 and on Spain's Electronic Market since
1998. This document is a press release, not a prospectus. This document does
not constitute or form part of an offering or invitation to sell or a
solicitation to purchase, offer or subscribe shares of the company. Moreover,
no reliance should be placed upon this document for any investment decision
or contract and it does not constitute a recommendation of any type with
regard to the shares of the company.

This note is also available on the PharmaMar web site:
www.pharmamar.com and at Zeltia's Web site: www.zeltia.com

PharmaMar, +34-91-444-4500