Senetek PLC Investor Hotline Goes Live

NAPA, California - Call +1-877-SENETEK or +1-707-259-6278

Senetek PLC (OTC Bulletin Board: SNKTY), a Life Sciences company engaged in the development of technologies that target the science of healthy aging, announced that an up-to-date audio recording of Company news and developments is now available by calling +1-877-SENETEK in the United States and Canada and +1-707-259-6278 from international locations.

“We are pleased to provide this service to our investors as a supplement to news releases, shareholder teleconferences and our quarterly and annual filings. Our mission is to keep the Senetek shareholder updated in a timely fashion,” stated Frank J. Massino, Chairman and Chief Executive Officer of Senetek.

About Senetek PLC:

Senetek PLC (OTCBB: SNKTY) is a life sciences company engaged in the development of breakthrough technologies that target the science of healthy aging. The company’s extensive research collaborations have resulted in a strong pipeline of patented compounds and products with broad therapeutic applications and a leading presence in dermatology. Senetek collaborates with established specialty pharmaceutical companies in the final development and marketing of its proprietary products, most recently resulting in the development of kinetin, the best-selling anti-aging product sold in the North American physician market. For more information, visit the company’s websites:

www.senetekplc.com www.pyratine6.com www.pyratinexr.com

or call: +1-877-SENETEK (United States and Canada) +1-707-259-6278 (International Locations)

This news release contains statements that may be considered ‘forward-looking statements’ within the meaning of the Private Securities Litigation Reform Act. Forward-looking statements by their nature involve substantial uncertainty, and actual results may differ materially from those that might be suggested by such statements. Important factors identified by the Company that it believes could result in such material differences are described in the Company’s Annual Report on Form 10-K for the year 2008. However, the Company necessarily can give no assurance that it has identified or will identify all of the factors that may result in any particular forward-looking statement materially differing from actual results, and the Company assumes no obligation to correct or update any forward-looking statements which may prove to be inaccurate, whether as a result of new information, future events or otherwise.

Source: Senetek PLC

William O’Kelly of Senetek, PLC, +1-707-226-3900, ext. 102 or Media, Maggie Carr, maggie at michaelrogerspr.com, or Michael Rogers, michael at michaelrogerspr.com, both of Michael Rogers Public Relations, +1-212-255-7210, ext. 22, for Senetek, PLC