Medtronic Announces Collaboration With Tissuemed for Exclusive Distribution of Innovative Neurosurgical Film

MINNEAPOLIS, October 4, 2010 - Medtronic, Inc. (NYSE: MDT) today announced it will distribute Obex
NeuroFilm(TM) Cerebrospinal Fluid Barrier in markets outside the US in
collaboration with Tissuemed, a leading company in the research, development,
design and manufacture of products utilizing adhesive polymer technology for
medical applications.

Under the terms of its agreement with Tissuemed, Medtronic will act as
exclusive distributor for the Obex NeuroFilm(TM) barrier, selling the product
through its direct operations and partners in most of Europe as well as other
key markets.

The Obex NeuroFilm(TM) product is a synthetic ready-to-use self-adhesive
barrier for cerebrospinal fluid (CSF) leak prevention. It acts as a sealant
which is commonly placed over a suture line or other repaired dura resulting
from a neurosurgical procedure. The film clings to tissue and bonds, forming
a seal over the tissue surface within 30 seconds.

The Obex NeuroFilm(TM) barrier gives surgeons the flexibility to work
immediately to seal any openings from sutures or other dural repairs, helping
to create a water-tight seal to prevent leakage of cerebrospinal fluid. This
bioresorbable product stays where it is applied, remaining intact until it is
largely absorbed in the weeks following a neurosurgical procedure.

A preclinical study has shown that the Obex NeuroFilm(TM) sealant has the
potential to provide a useful adjunct in the reduction of CSF leaks during
and after neurosurgical procedures.

"We are pleased to collaborate with Tissuemed to bring this revolutionary
product to surgeons," said Mark Fletcher, president of the Neuro Technologies
and ENT businesses at Medtronic. "The Obex NeuroFilm product is an important
strategic addition to our industry-leading portfolio of products for
neurosurgeons."

"Medtronic is a global leader in medical device technology and we look
forward to leveraging our partnership for the benefit of surgeons and
patients," said Nick Woods, CEO of Tissuemed. "We are pleased to offer this
easy-to-use, innovative solution to operative challenges faced by
neurosurgeons that may help improve patient outcomes."

About the Surgical Technologies Business at Medtronic

The Surgical Technologies business develops products for the diagnosis
and treatment of chronic diseases and disorders of the ear, nose and throat;
surgical devices and implantable products for the treatment of cranial,
spinal and specialty small-bone conditions; and state-of-the-art navigation
equipment used in operating rooms to assist physicians in neuro and spinal
surgery procedures.

About Medtronic

Medtronic, Inc. (www.medtronic.com), headquartered in Minneapolis,
is the global leader in medical technology - alleviating pain, restoring
health, and extending life for millions of people around the world.

About Tissuemed

Tissuemed, based in Leeds, UK, is a leading medical device company with a
reputation for technical innovation dating back over twenty years. The
company has its origins in the development of tissue-based therapeutic
devices including developing the first tissue heart valve to gain regulatory
approval in Europe, subsequently developing "living" vascular grafts and
collagen patches. The company developed light-activated surgical adhesives
for which Tissuemed was the Gold Winner of the Medical Design Excellence
Award in 2001.

Any forward-looking statements are subject to risks and uncertainties
such as those described in Medtronic's periodic reports on file with the
Securities and Exchange Commission. Actual results may differ materially from
anticipated results.

Obex NeuroFilm(TM) is a trademark of Medtronic, Inc. Tissuemed(R) is a
registered trademark of Tissuemed Ltd.

Contacts: Jeff Warren, Investor Relations, +1-763-505-2696; Brian Henry, Public Relations, +1-763-505-2796