Pfizer Oncology To Present New Clinical Data Across Ten Tumor Types and Multiple Molecular Targets

Updated Study Results to be Presented on ALK inhibitor (PF-02341066) and Pan-HER Inhibitor (PF-00299804) in Non-Small Cell Lung Cancer

NEW YORK, October 7, 2010 - Pfizer Oncology will present new data across its portfolio representing
novel approaches to researching treatments for patients with rare and
difficult-to-treat cancers. These results will be presented at the 35th
European Society for Medical Oncology (ESMO) Congress in Milan, Italy from
October 8-12.

    (Logo: photos.prnewswire.com/prnh/20100416/PFIZERLOGO )
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"Pfizer (NYSE: PFE) has focused its oncology research on targeting
molecular drivers and pathways in various cancers, such as EGFR, ALK and
IGF-1R," said Dr. Mace Rothenberg, senior vice president of clinical
development and medical affairs for Pfizer's Oncology Business Unit. "We are
committed to using this approach to seek treatments for well-known,
difficult-to-treat and rare tumor types that have few or no therapeutic
options and where we can make a big impact in defined patient populations."

At ESMO, Pfizer will present data on key compounds from its portfolio,
which includes:

- PF-00299804

Updated results from a global, randomized Phase 2 trial evaluating the
anti-tumor activity and safety of PF-00299804 compared to erlotinib in
patients with NSCLC following progression on treatment with one or more
chemotherapy regimens (Abstract #365PD, October 10).(1) In addition,
preliminary efficacy and safety data from a Phase 2 study evaluating
PF-00299804 as first-line treatment in patients with advanced NSCLC whose
tumors are likely to carry the EGFR mutation will be presented as a late
breaker in a Proffered Paper session (Abstract #LBA18, October 11).(2)

PF-00299804 is an investigational, oral, pan-HER (pan-human epidermal
growth factor receptor) inhibitor.(2) PF-00299804 is currently being
evaluated in the BR.26 clinical trial, a Phase 3, double-blind,
placebo-controlled, randomized study in patients with stage IIIB/IV NSCLC who
have progressive disease following standard chemotherapy and EGFR inhibitor
therapy.(3) BR.26 is led by the NCIC Clinical Trials Group (CTG).(3)

- Crizotinib (PF-02341066)

Updated data on crizotinib (PF-02341066), a first-in-class, oral ALK
inhibitor, will also be presented, from the ongoing expansion cohort from the
Phase 1 study evaluating the compound in patients with ALK-positive advanced
NSCLC (Abstract #366PD, October 10).(4)

- Sunitinib

Pfizer will also present results from SUN 1087, a Phase 3 trial
evaluating sunitinib plus erlotinib compared to erlotinib alone in patients
with advanced NSCLC who have received at least one previous treatment with a
platinum-based regimen (Abstract #LBA6, October 11).(5) In August, Pfizer
announced that this study demonstrated a statistically significant
improvement in progression-free survival but not in overall survival. Overall
survival was the primary endpoint of the study and progression free survival
was the secondary endpoint of the study.

Pfizer will also present progression-free survival (PFS) data as
determined by blinded independent central review (BICR) from the pivotal,
placebo-controlled SUN 1111 Phase 3 trial evaluating sunitinib in patients
with progressive, well-differentiated pancreatic neuroendocrine tumor (NET)
(Abstract #747P, October 9).(6)

- Figitumumab

Results from a Phase 1/2 study evaluating figitumumab (CP-751,871), a
selective fully human IgG2 monoclonal antibody against the IGF-1R
(insulin-like growth factor 1 receptor) pathway, in patients with
refractory Ewing's sarcoma and other sarcomas will be presented in a
Proffered Paper session (Abstract #1344O, October 10).(7)

Pfizer continues to investigate approved therapies within its portfolio,
including Aromasin(R) (exemestane tablets). At the Congress, research
findings for the compound will be presented in two key presentations.

    - Distant recurrences at median of 5-years among 9,779 postmenopausal
      women with hormone receptor-positive early breast cancer treated on
      the TEAM trial of adjuvant endocrine therapy (Abstract #213O, October
      11)(8)

    - Effects of exemestane or tamoxifen on bone health within the Tamoxifen
      Exemestane Adjuvant Multinational (TEAM) trial: a meta-analysis
      (Abstract #225P, October 10)(9)

Data on the following compounds and investigational agents will also be
presented: neratinib (HER2 positive breast, solid tumors),(10),(11) axitinib
(renal cell carcinoma or RCC),(12) inotuzumab (non-Hodgkin's lymphoma),(13)
and Torisel(R) (temsirolimus) (RCC, solid tumors).(14),(15)

For more news and information, follow Pfizer Oncology at ESMO through
Twitter @pfizer_news (twitter.com/pfizer_news).

About Sutent(R) (sunitinib malate)

Sutent is an oral multi-kinase inhibitor approved for the treatment of
advanced RCC and for the treatment of GIST after disease progression on or
intolerance to imatinib mesylate.

Sutent works by blocking multiple molecular targets implicated in the
growth, proliferation and spread of cancer. Two important Sutent targets,
vascular endothelial growth factor receptor (VEGFR) and platelet-derived
growth factor receptor (PDGFR), are expressed by many types of solid tumors
and are thought to play a crucial role in angiogenesis, the process by which
tumors acquire blood vessels, oxygen and nutrients needed for growth. Sutent
also inhibits other targets important to tumor growth, including KIT, FLT3
and RET.

Important Sutent(R) (sunitinib malate) Safety Information

Hepatotoxicity has been observed in clinical trials and post-marketing
experience. This hepatotoxicity may be severe, and deaths have been reported.
It is recommended to monitor liver function tests before initiation of
treatment, during each cycle of treatment, and as clinically indicated.
Sutent should be interrupted for Grade 3 or 4 drug-related hepatic adverse
events and discontinued if there is no resolution. Sutent should not be
restarted if patients subsequently experience severe changes in liver
function tests or have other signs and symptoms of liver failure.

Women of child bearing age who are (or become) pregnant during therapy
should be informed of the potential for fetal harm while on Sutent.

Decreases in left ventricular ejection fraction (LVEF) to below the lower
limit of normal (LLN) have been observed. Patients with concomitant cardiac
conditions should be carefully monitored for clinical signs and symptoms of
congestive heart failure. Patients should be monitored for hypertension and
treated as needed with standard antihypertensive therapy. Complete blood
counts (CBCs) with platelet count and serum chemistries should be performed
at the beginning of each treatment cycle for patients receiving treatment
with Sutent.

The most common adverse reactions in GIST and RCC clinical trials were
diarrhea, fatigue, asthenia, nausea, mucositis/stomatitis, anorexia,
vomiting, hypertension, dyspepsia, abdominal pain, constipation, rash,
hand-foot syndrome, skin discoloration, altered taste and bleeding.

For more information on Sutent including full prescribing information
please visit www.pfizer.com.

About Aromasin(R) (exemestane tablets)

Aromasin is the only aromatase inhibitor indicated for sequential therapy
in postmenopausal women with hormone-receptor (HR) positive early breast
cancer after two to three years of tamoxifen for a total of five years of
adjuvant therapy. The use of Aromasin in this setting is supported by the
landmark IES trial. Aromasin is also indicated for the treatment of advanced
breast cancer in postmenopausal women whose disease has progressed following
tamoxifen therapy.

Important Aromasin (exemestane tablets) Safety Information

Aromasin should not be used in women who are premenopausal, are nursing
or pregnant, have a known hypersensitivity to the drug, or are taking
estrogen-containing agents. Dose modification is recommended for patients who
are receiving certain medications, including strong CYP 3A4 inducers. In
patients with early breast cancer, elevations in bilirubin, alkaline
phosphatase, and creatinine were more common in those receiving Aromasin than
either tamoxifen or placebo. Reductions in bone mineral density over time are
seen with the use of Aromasin.

For more information on Aromasin including full prescribing information
please visit www.pfizer.com.

About Torisel(R) (temsirolimus)

Torisel is the only intravenous mammalian target of rapamycin (mTOR)
inhibitor approved for the treatment of advanced renal cell carcinoma (RCC)
in the first-line setting.

Based on preclinical studies, Torisel inhibits the activity of mTOR, an
intracellular protein implicated in multiple growth-related cellular
functions including proliferation, growth and survival. The inhibition of
mTOR also reduces levels of certain growth factors, such as vascular
endothelial growth factor (VEGF), which are overexpressed in solid tumors
like kidney cancer and are thought to play a crucial role in angiogenesis,
the process by which tumors acquire blood vessels, nutrients and oxygen
needed for growth.

Important Torisel(R) (temsirolimus) Safety Information

Patients with moderate or severely impaired liver function should not
receive Torisel. Torisel should be used with caution and at a reduced dose in
those with mild liver function impairment. The use of Torisel may result in a
serious allergic reaction, therefore patients should be prescribed an
antihistamine before Torisel treatment.

Hypersensitivity reactions manifested by symptoms, including, but not
limited to anaphylaxis, dyspnea, flushing, and chest pain have been observed
with Torisel. Serum glucose, serum cholesterol, and triglycerides should be
tested before and during treatment with Torisel. The use of Torisel is likely
to result in hyperglycemia and hyperlipemia. This may result in the need for
an increase in the dose of, or initiation of, insulin and/or oral
hypoglycemic agent therapy and/or lipid-lowering agents, respectively.

The use of Torisel may result in immunosuppression. Patients should be
carefully observed for the occurrence of infections, including opportunistic
infections. Cases of interstitial lung disease, some resulting in death, have
occurred. Some patients were asymptomatic and others presented with symptoms.
Some patients required discontinuation of Torisel and/or treatment with
corticosteroids and/or antibiotics. Cases of fatal bowel perforation occurred
with Torisel. These patients presented with fever, abdominal pain, metabolic
acidosis, bloody stools, diarrhea, and/or acute abdomen. Cases of rapidly
progressive and sometimes fatal acute renal failure not clearly related to
disease progression occurred in patients who received Torisel.

Due to abnormal wound healing, use Torisel with caution in the
perioperative period. Patients with central nervous system tumors (primary
CNS tumor or metastases) and/or receiving anticoagulation therapy may be at
an increased risk of developing intracerebral bleeding (including fatal
outcomes) while receiving Torisel. Live vaccinations and close contact with
those who received live vaccines should be avoided. Patients and their
partners should be advised to avoid pregnancy throughout treatment and for 3
months after Torisel therapy has stopped.

The most common (incidence >/= 30 percent) adverse reactions observed
with Torisel are: rash (47 percent), asthenia (51 percent), mucositis (41
percent), nausea (37 percent), edema (35 percent), and anorexia (32 percent).
The most common laboratory abnormalities (incidence >/= 30 percent) are
anemia (94 percent), hyperglycemia (89 percent), hyperlipemia (87 percent,
hypertriglyceridemia (83 percent), elevated alkaline phosphatase (68
percent), elevated serum creatinine (57 percent), lymphopenia (53 percent),
hypophosphatemia (49 percent), thrombocytopenia (40 percent), elevated AST
(38 percent), and leukopenia (32 percent). Most common grades 3/4 adverse
events included asthenia (11 percent), dyspnea (9 percent), hemoglobin
decreased (20 percent), lymphocytes decreased (16 percent), glucose increased
(16 percent), phosphorus decreased (18 percent), and triglycerides increased
(44 percent).

Strong inducers of CYP3A4/5 (e.g., dexamethasone, rifampin) and strong
inhibitors of CYP3A4 (e.g., ketoconazole, atazanavir) may decrease and
increase concentrations of the major metabolite of TORISEL, respectively. If
alternatives cannot be used, dose modifications of Torisel are recommended.
St. John's Wort may decrease Torisel plasma concentrations, and grapefruit
juice may increase plasma concentrations of the major metabolite of Torisel,
and therefore both should be avoided. The combination of Torisel and
sunitinib resulted in dose-limiting toxicity (Grade 3/4 erythematous
maculopapular rash, and gout/cellulitis requiring hospitalization).

For more information on Torisel, including full prescribing information
please visit www.pfizer.com.

About Pfizer Oncology

Pfizer Oncology is committed to the discovery, investigation and
development of innovative treatment options to improve the outlook for cancer
patients worldwide. Our strong pipeline, one of the most robust in the
industry, is studied with precise focus on identifying and translating the
best scientific breakthroughs into clinical application for patients across a
wide range of cancers, including lung, breast, prostate, sarcoma, melanoma,
and various hematologic cancers. Pfizer Oncology has biologics and small
molecules in clinical development and more than 200 clinical trials underway.

By working collaboratively with academic institutions, individual
researchers, cooperative research groups, governments, and licensing
partners, Pfizer Oncology strives to cure or control cancer with breakthrough
medicines, to deliver the right drug for each patient at the right time. For
more information please visit www.Pfizer.com.

DISCLOSURE NOTICE: The information contained in this release is as of
October 7, 2010. Pfizer assumes no obligation to update any forward-looking
statements contained in this release as the result of new information or
future events or developments.

This release contains forward-looking information about various oncology
product candidates and potential additional indications for various in-line
oncology products, including their potential benefits, that involves
substantial risks and uncertainties. Such risks and uncertainties include,
among other things, the uncertainties inherent in research and development;
decisions by regulatory authorities regarding whether and when to approve any
drug applications or supplemental drug applications that have been or may be
filed for any such oncology product candidates or any such additional
indications for in-line oncology products as well as their decisions
regarding labeling and other matters that could affect their availability or
commercial potential; and competitive developments.

A further description of risks and uncertainties can be found in Pfizer's
Annual Report on Form 10-K for the fiscal year ended December 31, 2009 and in
its reports on Form 10-Q and Form 8-K.

(1) ESMO Accepted Abstract #365PD. Randomized phase 2 study of PF299804,
an irreversible human epidermal growth factor receptor (EGFR) inhibitor,
versus (v) erlotinib (E) in patients (pts) with advanced non-small cell lung
cancer (NSCLC) after chemotherapy (CT) failure: quantitative and qualitative
benefits. Poster Discussion. Sunday, October 10: 12:30 pm. Suresh Ramalingam
- Presenter. 35th Congress of the European Society for Medical Oncology.
Milan, Italy. October 8 - 12, 2010.

(2) ESMO Accepted Abstract # LBA18. Efficacy and safety of PF299804 as
first-line treatment (tx) of patients (pts) with advanced non-small cell lung
cancer (NSCLC) selected for activating mutation (mu) of epidermal growth
factor receptor (EGFR). Proffered Paper (Oral Presentation). Monday, October
11: 14:00. Tony Mok - Presenter. 35th Congress of the European Society for
Medical Oncology. Milan, Italy. October 8 - 12, 2010.

(3) ClinicalTrials.gov. PF-00299804 in Treating Patients With Stage IIIB
or Stage IV Non-Small Cell Lung Cancer That Has Not Responded to Standard
Therapy for Advanced or Metastatic Cancer. Available at:
clinicaltrials.gov/ct2/show/NCT01000025. Accessed April 29, 2010.

(4) ESMO Accepted Abstract # 366PD. Clinical Activity of Crizotinib
(PF-02341066), in ALK-Positive Patients with Non-Small Cell Lung Cancer
(NSCLC). Poster Discussion. Sunday, October 10: 12:30. David Ross Camidge -
Presenter. 35th Congress of the European Society for Medical Oncology. Milan,
Italy. October 8 - 12, 2010.

(5) ESMO Accepted Abstract # LBA6. Sunitinib (SU) in combination with
erlotinib (E) for the treatment of advanced/metastatic non-small cell lung
cancer (NSCLC): a phase III study. Proferred Paper. Monday, October 11:
10:30-10:45. Giorgio V Scagliotti - Presenter. 35th Congress of the European
Society for Medical Oncology. Milan, Italy. October 8 - 12, 2010.

(6) ESMO Accepted Abstract #747P. Evaluation of progression-free survival
(PFS) by blinded independent central review (BICR) in patients (pts) with
progressive, well-differentiated pancreatic neuroendocrine tumours (NET)
treated with sunitinib (SU) or placebo. Poster Presentation. Saturday,
October 9: 13:00-14:00. Eric van Cutsem - Presenter. 35th Congress of the
European Society for Medical Oncology. Milan, Italy. October 8 - 12, 2010.

(7) ESMO Accepted Abstract #1344O. Safety and Efficacy Results from a
Phase 1/2 Study of the Anti-IGF-IR Antibody Figitumumab in Patients with
Refractory Ewing's and Other Sarcomas. Proferred Paper. Sunday, October 10:
9:15-9:30. Heribert Juergens - Presenter. 35th Congress of the European
Society for Medical Oncology. Milan, Italy. October 8 - 12, 2010.

(8) ESMO Accepted Abstract #213O. Distant recurrences at median of
5-years among 9.779 postmenopausal women with hormone receptor-positive early
breast cancer treated on the TEAM trial of adjuvant endocrine therapy.
Proffered Paper. Monday, October 11: 9:00-9:15. Hans Nortier - Presenter.
35th Congress of the European Society for Medical Oncology. Milan, Italy.
October 8 - 12, 2010.

(9) ESMO Accepted Abstract #225P. Effects of exemestane or tamoxifen on
bone health within the Tamoxifen Exemestane Adjuvant Multinational (TEAM)
trial: a meta-analysis. Poster Presentation. Sunday, October 11: 12:30-13:30.
Peyman Hadji - Presenter. 35th Congress of the European Society for Medical
Oncology. Milan, Italy. October 8 - 12, 2010.

(10) ESMO Accepted Abstract #292P. Evaluation of Neratinib (HKI-272) and
Paclitaxel Pharmacokinetics (PK) in Asian and Caucasian Patients with ErbB2+
Breast Cancer: A Phase 1/2 Study of Neratinib in Combination with Paclitaxel.
Poster Presentation. Saturday, October 9: 13:00-14:00. Richat Abbas -
Presenter. 35th Congress of the European Society for Medical Oncology. Milan,
Italy. October 8 - 12, 2010.

(11) ESMO Accepted Abstract #298P. A Phase 1 Study of Neratinib (HKI-272)
in Combination with Paclitaxel in Japanese Patients with Solid Tumors. Poster
Presentation. Saturday, October 9: 13:00-14:00. Yoshinori Ito - Presenter.
35th Congress of the European Society for Medical Oncology. Milan, Italy.
October 8 - 12, 2010.

(12) ESMO Accepted Abstract #907P. Axitinib Pharmacokinetics and Blood
Pressure Changes in Front-line Metastatic Renal Cell Carcinoma (RCC)
Patients. Poster Presentation. Saturday, October 9: 13:00-14:00. Mayer N.
Fishman - Presenter. 35th Congress of the European Society for Medical
Oncology. Milan, Italy. October 8 - 12, 2010.

(13) ESMO Accepted Abstract #1152P. Modeling the
Pharmacokinetic/Pharmacodynamic Platelet Response of Inotuzumab Ozogamicin, a
Novel Antibody Drug Conjugate, Administered Alone or in Combination with
Rituximab in Patients With Non-Hodgkin's Lymphoma. Poster Presentation.
Monday, October 11: 12:30-13:30. Joseph Boni - Presenter. 35th Congress of
the European Society for Medical Oncology. Milan, Italy. October 8 - 12,
2010.

(14) ESMO Accepted Abstract #926P. A phase 2 study of safety and efficacy
of temsirolimus (CCI-779) administered as a single agent in East Asian
patients with advanced renal cell carcinoma. Poster Presentation. Saturday,
October 9: 13:00-14:00. Yan Sun - Presenter. 35th Congress of the European
Society for Medical Oncology. Milan, Italy. October 8 - 12, 2010.

(15) ESMO Accepted Abstract #549P. Population Pharmacokinetics of
Temsirolimus in Pediatric Patients with Relapsed/Refractory Solid Tumors.
Poster Presentation. Monday, October 11: 12:30-13:30. Sam Liao - Presenter.
35th Congress of the European Society for Medical Oncology. Milan, Italy.
October 8 - 12, 2010.

Curtis Allen, +1-212-733-2096, +1-347-443-5252, Achim Janik, +49(0)170-5772967; Investors Contact: Jennifer Davis, +1-212-733-0717