Shire plc : Second Quarter 2011 Results Date Notification - July 28, 2011

DUBLIN, July 15, 2011 -

Shire plc (LSE: SHP, NASDAQ: SHPGY), the global specialty
biopharmaceutical company, will announce second quarter 2011
earnings on Thursday July 28, 2011.

    Results press release will be
    issued at:                    12:00 BST / 07:00 EDT
    Investor conference call
    time:                         14:00 BST / 09:00 EDT

Live conference call for
investors:

Angus Russell, Chief Executive Officer and Graham Hetherington,
Chief Financial Officer will host the investor and analyst
conference call at 14:00 BST/9:00 EDT.

The details of the conference call are as follows:

    UK dial in:          0800-077-8492 or 0844-335-0351
    US dial in:          +1-866-8048688 or +1-718-3541175
    International dial
    in:                  +44-208-974-7900

Global Access Numbers:     href="www.btconferencing.com/globalaccess/?bid=54_attended">www.btconferencing.com/globalaccess/?bid=54_attended

Password/Conf ID:    818 608

Live Webcast:     href="www.shire.com/shireplc/en/investors">www.shire.com/shireplc/en/investors

Replay:

A replay of the presentation will be available for two weeks by
phone and by webcast for one year.  Details can be found on
our Investor Relations website href="www.shire.com/shireplc/en/investors">www.shire.com/shireplc/en/investors.

Notes to editors

SHIRE PLC

Shire’s strategic goal is to become the leading specialty
biopharmaceutical company that focuses on meeting the needs of the
specialist physician.  Shire focuses its business on attention
deficit hyperactivity disorder (ADHD), human genetic therapies
(HGT) and gastrointestinal (GI) diseases as well as opportunities
in other therapeutic areas to the extent they arise through
acquisitions.  Shire’s in-licensing, merger and acquisition
efforts are focused on products in specialist markets with strong
intellectual property protection and global rights.  Shire
believes that a carefully selected and balanced portfolio of
products with strategically aligned and relatively small-scale
sales forces will deliver strong results.

For further information on Shire, please visit the Company’s
website: href="www.shire.com/">www.shire.com.

For further information please
contact:

    Investor Relations Souheil Salah (ssalah@shire.com) +44-1256-894-160
                       Erin Kelly (erikelly@shire.com)  +1-781-482-9541

.