2011 ACCF/AHA Guidelines Incorporate New Recommendation for Platelet Reactivity Testing

By Accumetrics Inc., PRNE
Wednesday, March 30, 2011

Platelet Function Testing May Be Used to Aid Patient Management

SAN DIEGO, March 31, 2011 - Accumetrics, Inc., developer of the VerifyNow(R) System, the first rapid
and easy-to-use point-of-care system for measuring platelet reactivity to
multiple antiplatelet agents, announced today that a new recommendation for
platelet reactivity testing has been incorporated into the updated 2011
ACCF/AHA Guidelines for the Management of UA/NSTEMI Patients.

The Guidelines, published online in the Journal of the American College
of Cardiology(1), signify the growing focus and importance of platelet
reactivity testing in a variety of patient populations, including UA/NSTEMI
and ACS/PCI. The IIb (B) recommendation suggests that an approach of
assessing platelet reactivity in combination with other procedural and
patient characteristics may be considered to aid in patient management

"The addition of platelet reactivity testing to the Guidelines captures
what we have already implemented at Scripps," said Matthew J. Price, MD, of
the Scripps Translational Science Institute and Scripps Clinic in La Jolla,
. "We believe that when considering alternative approaches for the
management of patients that require antiplatelet therapy, an individualized
approach that incorporates platelet reactivity testing is warranted in an
attempt to minimize further ischemic events."

The Update also provides guidance on the rapidly expanding treatment
options for patients requiring antiplatelet medications. "With the
availability of newer antiplatelet agents, it has become challenging for a
physician to determine how to manage individual patients," stated Kevin
, MD, PhD, Interventional Cardiologist at Brigham and Women's Hospital.
"By utilizing platelet reactivity testing as recommended in this new
Guideline, we feel we have a clearer picture on how to optimally manage our
patients at the Brigham in this increasingly complex clinical setting."

The release of these Guidelines further elevates awareness of platelet
reactivity testing as an important topic, and sets the stage for additional
data and discussions at the 2011 ACC Scientific Sessions. New data from a
patient-level meta-analysis will be presented by Dr. Somjot Brar on April
, and Dr. Paul Gurbel and Dr. Matthew Price will discuss "The Application
of Available Data in Clinical Practice" during the Accumetrics Industry
Expert Theater Program on April 4th.

"The ACCF/AHA UA/NSTEMI Guidelines follow the STS/SCA Blood Conservation
Guidelines released earlier this month, reinforcing the clinical importance
of point-of-care platelet reactivity testing," said Timothy I. Still,
President and CEO of Accumetrics. "With the VerifyNow System, Accumetrics is
proud to be the leader in providing this critically important information to
aid in the management of patients."

The VerifyNow System is widely used in various clinical settings where
antiplatelet medications are prescribed to reduce the occurrence of future
thrombotic events such as heart attack and stroke.

About Accumetrics

Accumetrics is committed to advancing medical understanding of platelet
function and enhancing quality of care for patients receiving antiplatelet
therapies by providing industry-leading and widely accessible diagnostic
tests for rapid platelet function assessment.

Accumetrics' VerifyNow System is the first rapid and easy-to-use platform
to help physicians determine an individual's response to multiple
antiplatelet agents. Addressing every major antiplatelet drug, including
FDA-cleared products for aspirin, P2Y12 inhibitors (e.g. prasugrel
(Effient(R)) and clopidogrel (Plavix(R))), and GP IIb/IIIa inhibitors (e.g.
ReoPro(R) and Integrilin(R)), the VerifyNow System provides valuable
information to help physicians make informed treatment decisions. For more
information about the Company and its products, visit www.accumetrics.com.

The Accumetrics logo and VerifyNow are registered trademarks of
Accumetrics, Inc. ReoPro is a registered trademark of Centocor, Inc.
Integrilin is a registered trademark of Millennium Pharmaceuticals. Plavix is
a registered trademark of sanofi-aventis. Effient is a registered trademark
of Eli Lilly and Company.

(1) Wright RS, Anderson JL, Adams CD, et al. 2011 ACCF/AHA Focused Update
of the Guidelines for the Management of Patients With Unstable Angina/Non
ST-Elevation Myocardial Infarction (Updating the 2007 Guideline): A Report of
the American College of Cardiology Foundation/American Heart Association Task
Force on Practice Guidelines. J. Am. Coll. Cardiol. Published online Mar 28,
; doi:10.1016/j.jacc.2011.02.009.

    Jakob Jakobsen

    Timothy I. Still
    President and CEO


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