Published in "Bone" Journal, Scientific Researches Confirm Peptan(TM) Hydrolyzed Collagen Benefits on Bone Health

Studies Conducted at INRA-Agroparistech Laboratory Under Pr. Daniel Tome's Supervision and Published* in November 2009, in the Official Journal of the International Bone and Mineral Society "Bone", Reveal new Benefits for Peptan(TM) in Osteoporosis Prevention

PUTEAUX, France, December 16 - In response to consumer concerns regarding long-term bone health,
Rousselot has carried out, for several years now, many studies to
demonstrate that an oral intake of Peptan(TM) may have a positive impact on
osteoporosis.

Bone is a living dynamic metabolic system that relies on a
maintained balance between bone formation and bone resorption. Cells called
osteoblasts make bone while cells called osteoclasts resorb it. An imbalance
may lead to osteoporosis, a condition where the density and quality of bone
is reduced.

Researchers conducted in vitro studies, and highlighted that
Peptan(TM) in bone cell culture induced a better differentiation of
osteoblasts. Those positive results have then been confirmed in vivo on
ovariectomized mice, used to simulate a postmenopausal osteoporosis, which
leads to a lower bone mineral density (BMD).

Animals were divided into three groups: a control group (non
ovariectomized), a group of ovariectomized mice, both fed with a normal diet
and a group of ovariectomized mice that received a diet containing
Peptan(TM). After 12 weeks, the BMD of the group fed with Peptan(TM) is not
significantly different from the BMD of control group. On the contrary the
BMD of ovariectomized mice not fed with Peptan(TM) is lower.

Confirmation of Peptan(TM) benefits on bone health has been
obtained by the measures of Carboxy Terminal Telopeptide (CTX), a usual
marker of bone resorption. CTX is significantly lower in mice fed with
Peptan(TM) indicating that bone resorption is reduced.

Researchers conclude that Peptan(TM) may restore bone density in
simulated post-menopausal osteoporosis by stimulating osteoblast growth and
differentiation. This demonstrates the interest of Peptan(TM) as a bioactive
ingredient to help preventing bone loss during aging.

*Hydrolyzed collagen improves bone metabolism and biomechanical
parameters in ovariectomized mice: an in vitro and in vivo study.
Guillerminet et al. Bone 2009.

Rousselot, www.rousselot.com

Part of VION N.V. (N.L.), Rousselot(R) is the worldwide leader
in gelatine and hydrolyzed collagen. VION N.V. is an internationally
operating food group that produces high-quality foods and ingredients for
humans and animals (Turnover: EUR 9.6 billion - 31,000 employees worldwide)

Caroline Brochard-Garnier, Communication, +33-1-46-67-87-27, caroline.brochard-garnier at rousselot.com