Senetek PLC Announces New Investor Communication Hotline

NAPA, California - Senetek PLC (OTC Bulletin Board: SNKTY), a Life Sciences company engaged in the development of technologies that target the science of healthy aging, today announced plans for the creation of a new communication hotline for the expressed purpose of keeping the investment community updated on key events. Bi-weekly updates will be recorded on a designated call-in number which is targeted to be up and running in early May. In addition, callers will be able to leave their contact information regarding any questions they may have.

The Company will periodically supplement the hotline with live investor teleconferences to announce and discuss significant material events. Frank J. Massino, Chairman and Chief Executive Officer stated, “that in today’s volatile business and political environments, it is important to keep our shareholders updated in a timely manner on events shaping the Company.”

About Senetek PLC:

Senetek PLC (OTCBB: SNKTY) is a Life Sciences company engaged in the development of breakthrough technologies that target the science of healthy aging. The company’s extensive research collaborations have resulted in a strong pipeline of patented compounds and products with broad therapeutic applications and a leading presence in dermatology. Senetek collaborates with established specialty pharmaceutical companies in the final development and marketing of its proprietary products, most recently resulting in the development of kinetin, the best-selling anti-aging product sold in the North American physician market. For more information, visit the company’s websites: www.senetekplc.com www.pyratine-6.com www.pyratinexr.com

This news release contains statements that may be considered ‘forward-looking statements’ within the meaning of the Private Securities Litigation Reform Act. Forward-looking statements by their nature involve substantial uncertainty, and actual results may differ materially from those that might be suggested by such statements. Important factors identified by the Company that it believes could result in such material differences are described in the Company’s Annual Report on Form 10-K for the year 2008. However, the Company necessarily can give no assurance that it has identified or will identify all of the factors that may result in any particular forward-looking statement materially differing from actual results, and the Company assumes no obligation to correct or update any forward-looking statements which may prove to be inaccurate, whether as a result of new information, future events or otherwise.

Source: Senetek PLC

Company, William O’Kelly of Senetek PLC, +1-707-226-3900 ext. 102; or Media, Maggie Carr, maggie at michaelrogerspr.com, or Michael Rogers, michael at michaelrogerspr.com, both of Michael Rogers Public Relations, +1-212-255-7210 ext. 22, for Senetek PLC