Third Quarter 2011 Results Date Notification - October 28, 2011

DUBLIN, Ireland, October 13, 2011 -

Shire plc (LSE: SHP, NASDAQ: SHPGY), the global specialty biopharmaceutical company, will announce third quarter 2011 earnings on Friday October 28, 2011.

    Results press release will be issued at:        12:00 BST / 07:00 EDT
    Investor conference call time:                  14:00 BST / 09:00 EDT

Live conference call for investors:

Angus Russell, Chief Executive Officer and Graham Hetherington, Chief Financial Officer will host the investor and analyst conference call at 14:00 BST/9:00 EDT.

The details of the conference call are as follows:

    
    UK dial in: 0800-077-8492 or 0844-335-0351
    US dial in: 1-866-8048688 or 1-718-3541175
    International dial in: +44-208-996-3900
    Global Access Numbers: www.btconferencing.com/globalaccess/?bid=54_attended
    Password/Conf ID: 280 117
    Live Webcast: www.shire.com/shireplc/en/investors

Replay:

A replay of the presentation will be available for two weeks by phone and by webcast for one year.  Details can be found on our Investor Relations website www.shire.com/shireplc/en/investors.

Notes to editors

SHIRE PLC

Shire’s strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician.  Shire focuses its business on attention deficit hyperactivity disorder, human genetic therapies, gastrointestinal diseases and regenerative medicine, as well as opportunities in other therapeutic areas to the extent they arise through acquisitions.  Shire’s in-licensing, merger and acquisition efforts are focused on products in specialist markets with strong intellectual property protection and global rights.  Shire believes that a carefully selected and balanced portfolio of products with strategically aligned and relatively small-scale sales forces will deliver strong results.

For further information on Shire, please visit the Company’s website: www.shire.com.

For further information please contact:

Investor Relations
Souheil Salah (ssalah@shire.com)
+44-1256-894-160

Erin Kelly (erikelly@shire.com)
+1-781-482-9541

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