Breakthrough in vivo Scientific Study Published: TA-65 Increases Healthspan, Renews Organ Systems, and Increases Critically Short Telomere Lengths

MALAGA, Spain, April 12, 2011 - Groundbreaking research touting the benefits of telomerase activation has
been published in Aging Cell, the # 1 journal in geriatrics and gerontology.

    (Photo: photos.prnewswire.com/prnh/20100908/NY60832-a)
    (Logo: photos.prnewswire.com/prnh/20100908/NY60832LOGO-b )

The study, "The Telomerase Activator TA-65 (www.tasciences.com)
elongates short telomeres and increases healthspan of adult/old mice without
increasing cancer incidence" describes TA-65's mechanism of action and
organismal response.

Over the past year, several recent papers have been published showing
telomerase activation having profound effects on health span without any
increase in tumorigenesis or other negative side effects. Published in
Rejuvenation Research in Sept 2010, a peer reviewed paper titled "A Natural
Product Telomerase Activator as Part of a Health Maintenance Program"
demonstrated that TA-65 transiently activates telomerase, lengthens short
telomeres, and rescues and restores the aging immune system in humans.

In November 2010, Harvard Medical School published a sensational article
where they reversed aging in mammals for the first time ever! They
demonstrated that Telomerase Activation (TA) caused rejuvenation of cells in
the brain, spleen, and reproductive organs. Mice that were the equivalent to
80 year old humans had their biological age reversed to that of young adults.
In a more recent study, the same Harvard researchers announced that they
believe telomere shortening to be the root cause of aging. They describe how
shortened telomeres lead to P53 activation and eventual mitochondrial
degradation which signals cell aging.

Now, Maria Blasco, the head of the National Cancer Research Center in
Spain, and her colleagues show that TA-65, a naturally occurring molecule
derived from the Astragalus plant, activates the telomerase enzyme, lengthens
critically short telomeres, rescues cells in various organ systems, and
improves healthspan. None of which was seen in the control group.

The Blasco study states, "TA-65 dietary supplementation in female mice
leads to an improvement of certain health-span indicators including glucose
tolerance, osteoporosis and skin fitness, without significantly increasing
global cancer incidence."

According to Noel Thomas Patton, founder of TA Sciences, "This study
proves the efficacy and legitimacy of TA-65. For the first time in medical
history there is something which has the potential to effectively lessen and
possibly eliminate the crippling effects of aging decline and degradation
caused by insufficient telomerase and short telomeres."

Please see below the abstract from Aging Cell.

Abstract

Here, we show that a small-molecule activator of telomerase (TA-65)
purified from the root of Astragalus membranaceus is capable of increasing
average telomere length and decreasing the percentage of critically short
telomeres and of DNA damage in haploinsufficient mouse embryonic fibroblasts
(MEFs) that harbor critically short telomeres and a single copy of the
telomerase RNA Terc gene (G3 Terc+/-MEFs). Importantly, TA-65 does not cause
telomere elongation or rescues DNA damage in similarly treated
telomerase-deficient G3 Terc-/- littermate MEFs. These results indicate that
TA-65 treatment results in telomerase-dependent elongation of short telomeres
and rescue of associated DNA damage, thus demonstrating that TA-65 mechanism
of action is through the telomerase pathway. In addition, we demonstrate that
TA-65 is capable of increasing mTERT levels in some mouse tissues and
elongating critically short telomeres when supplemented as part of a standard
diet in mice. Finally, TA-65 dietary supplementation in female mice leads to
an improvement of certain health-span indicators including glucose tolerance,
osteoporosis and skin fitness, without significantly increasing global cancer
incidence.

onlinelibrary.wiley.com/doi/10.1111/j.1474-9726.2011.00700.x/abstract

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