Elsevier's BrainNavigator 3.0 Reflects the Next Step in Enhancing Neurological Research

Digital Research Tool Now Includes Human and Rhesus Monkey Brain Content and Gene Expression Overlay

BURLINGTON, Massachusetts, October 5, 2010 - Elsevier (www.elsevier.com/), the leading publisher of
scientific, technical and medical information products and services, today
announced a new version of its online research tool BrainNavigator
(www.brainnav.com/). The first version, introduced in 2008, was well
received by the neuroscience researcher community and received the
prestigious PROSE Award (www.proseawards.com/current-winners.html) in
2009. In the updated version, BrainNavigator 3.0, Elsevier has added critical
new content and functionality to give researchers additional tools to
accelerate their research.

BrainNavigator now includes the Rhesus Monkey atlas, developed
by Editors-in-Chief, Professors George Paxinos and Charles Watson of the
University of New South Wales in collaboration with Michael Petrides from
McGill University in Montreal. BrainNavigator 3.0 also features the Atlas of
the Human Brain, developed by Dr. Paxinos, Prof. Jurgen Mai and Dr. Thomas
Voss at the University of Dusseldorf in Germany.

BrainNavigator is an online, interactive, 3D software tool
that extends and advances the application of brain atlases and maps images of
brain anatomy, helping neuroscience researchers save time and improve the
quality of their daily research. BrainNavigator helps locate the position of
structures within the brain, making visualization and communication about
scientific findings about the brain easier.

"With BrainNavigator 3.0 we've addressed the wish lists of
neuroscience researchers," said Suzanne BeDell, Managing Director of Elsevier
Science & Technology Books. "We've added even more cutting-edge content and
functions that streamline the way researchers work-from conceptualizing their
experiments to planning their surgeries to publishing their
findings-BrainNavigator is there every step of the way, speeding research and
improving results."

In addition to providing significant new functionalities designed to
further support the neuroscientist's workflow in the lab, the new version of
BrainNavigator continues to integrate digitized versions of the leading
atlases. Other new functions include:

    - Linking to the Allen Mouse Brain Atlas gene expression
    database. The open online Allen Mouse Brain Atlas, created by the Allen
    Institute for Brain Science (www.alleninstitute.org/), is a
    critical go-to resource for neuroscientists. Based on the Allen
    Institute's public application programming interface (API), users can
    now readily access Atlas data from within BrainNavigator. BrainNavigator
    3.0-both free and subscription versions-allows users to easily overlay
    this gene expression data with anatomical information, helping them
    visualize which genes are expressed in various regions of the brain and
    to plan their experiments with greater accuracy, efficiency and validity.

    - Create and save a series of slices from 3D to 2D.
    BrainNavigator 3.0 includes an improved version of its virtual brain
    slicing feature. Researchers are now able to determine the angle of the
    cut and subsequently virtually create a series of slices from one end of
    the brain to the other automatically, at their desired thickness. This
    process closely approaches the process in the lab with a real brain. The
    series of images can also be saved for use in the 2D Navigator for
    precise annotation and documentation of their work.

    - Inclusion of fiber tracts. Over 70 new structures have been
    added for each rodent atlas. They are available in the 2D browser and
    in the 3D models. Fiber tracts are often used as landmarks in the brain,
    and when used with the injection planning tool, they allow users to plan
    so they can avoid penetrating certain areas as needed.

    - Inclusion of the rat and mouse chemoarchitectonic atlases.
    The chemoarchitectonic images provide more accurate delineation of
    structures and having multiple sources to compare creates deeper
    understanding of the user's own research.

"Users of our open online Allen Mouse Brain Atlas have long
asked to be able to view our gene expression data in the anatomic framework
developed by George Paxinos and Charles Watson," said Allan Jones, Ph.D.,
chief exectuive officer of the Allen Institute for Brain Science. "Now, in
both free and subscription-based versions, users can bring our data into the
BrainNavigator environment and do just that."

Offering both free and subscription-based content,
BrainNavigator is used by the National Institutes of Health (NIH),
Massachusetts Institute of Technology (MIT), Stanford University and other
leading research institutions. Nothing in this press release constitutes or
should be inferred to be an endorsement or recommendation of any product,
service, or enterprise by the National Institutes of Health, any other agency
of the United States Government, or any employee of the United States
Government.

About BrainNavigator

BrainNavigator is a collaboration between Elsevier and the
Allen Institute for Brain Science, pairing Elsevier's vast neuroscience
content with technology derived from Allen Institute's cutting-edge Brain
Explorer(R) 3D software. Offering both free and subscription-based content,
this dynamic new resource represents a promising step towards new discoveries
in the advancement of brain research. All users will be able to browse images
and structures. Paid subscribers will enjoy using high resolution images,
adjustable virtual slicing and having the ability to annotate and save their
work and share it with their colleagues globally, among other features.
Details regarding BrainNavigator's functionality can be found at
www.brainnav.com/info.

About the Allen Institute for Brain Science

Launched in 2003, the Seattle-based Allen Institute for Brain
Science is an independent, 501(c)(3) non-profit medical research organization
dedicated to advancing brain research. Started with $100 million in seed
money from philanthropist Paul G. Allen, the Institute takes on projects at
the leading edge of science - far-reaching projects at the intersection of
biology and technology. The resulting data create publicly available
resources that fuel discovery for countless other researchers worldwide. The
Institute's data and tools are available on the Web free of charge at
www.alleninstitute.org.

About Neuroscience Research Australia

The work of Neuroscience Research Australia, formerly named
the Prince of Wales Medical Research Institute, is directed to understanding
the integrative actions of the brain and nervous system in health and
disease. The brain and spinal cord control and coordinate everything that we
think, speak, feel and do. Damage or disease of the brain produces
devastating results. It can leave you unable to move, unable to speak, unable
to control even your basic bodily functions. It may leave you with
debilitating chronic pain.

The scientists at Neuroscience Research Australia, Sydney,
Australia (www.powmri.edu.au) are dedicated to understanding every
aspect of the nervous system. They also focus on translating their research
into clinical practice to help diagnose and prevent disease and ultimately to
look for curative therapies. The world leading research covers everything
from cells, genes and molecules through to how the elderly walk, and from the
tiniest blood vessel to the control of breathing.

About Elsevier

Elsevier is a world-leading publisher of scientific, technical
and medical information products and services. The company works in
partnership with the global science and health communities to publish more
than 2,000 journals, including The Lancet (www.thelancet.com/) and
Cell (www.cell.com/), and close to 20,000 book titles, including major
reference works from Mosby and Saunders. Elsevier's online solutions include
SciVerse ScienceDirect (www.sciencedirect.com/), SciVerse Scopus
(www.scopus.com/), Reaxys (www.reaxys.com/), MD Consult
(www.mdconsult.com/) and Nursing Consult (
www.nursingconsult.com/), which enhance the productivity of science
and health professionals, and the SciVal suite (www.scival.com/) and
MEDai's Pinpoint Review (www.medai.com/), which help research and
health care institutions deliver better outcomes more cost-effectively.

A global business headquartered in Amsterdam, Elsevier
(www.elsevier.com/), employs 7,000 people worldwide. The company is
part of Reed Elsevier Group PLC (www.reedelsevier.com/), a
world-leading publisher and information provider, which is jointly owned by
Reed Elsevier PLC and Reed Elsevier NV. The ticker symbols are REN (Euronext
Amsterdam), REL (London Stock Exchange), RUK and ENL (New York Stock
Exchange).

    Media contact
    Harald Boersma
    Senior Manager, Corporate Relations, Elsevier
    H.Boersma@elsevier.com
    +31-20-485-27-36

Media contact: Harald Boersma, Senior Manager, Corporate Relations, Elsevier, H.Boersma at elsevier.com, +31-20-485-27-36