Global Bioenergies Succeeds in Creating a Bacterial Prototype That Produces Isobutene From Glucose

EVRY, France, October 6, 2010 - Global Bioenergies, located on the Genopole campus at Evry
(France), announces the first prototype of its manufacturing process for the
biological production of isobutene. It relies on the use of a bacterial
strain harboring an artificial metabolic pathway created by the company.

Global Bioenergies announces that it has reached a key
milestone in the development of its process for the transformation of
renewable resources into gaseous isobutene (also called isobutylene or
methylpropene). An initial series of bacterial strains were developed that
can produce isobutene by transforming glucose.

Marc Delcourt, co-founder and CEO of the company, states, "We
have achieved our goal to bioproduce isobutene in vivo ahead of target. We
are now concentrating our efforts on increasing both the rate and scale of
fermentation. We plan to carry out pilot plant tests prior to the industrial
exploitation of the process. This phase will require new financial
investment."

Philippe Marliere, co-founder and designer of the process, adds,
"We have taught a bacterium to convert glucose to isobutene through an
entirely novel process. The metabolic layout that we established passes by
3-hydroxy-isovalerate (also called 3-hydroxy-3-methylbutyrate). This chemical
intermediate, which is absent from natural bacteria is, in turn,
enzymatically converted into isobutene in our strains. The process is set up
in accordance with the patent application filed in July 2008."

Jean-Marc Paris, professor at the EcoleSuperieure de Physique et de
Chimie (Paris Tech) and a member of the Scientific Advisory Board, concludes,
"This is the first time that an artificial metabolic pathway, which
leads the production of a light olefin from renewable resources, has been
designed and assembled in a micro-organism. These results set a precedent for
the in-depth changes which the worldwide chemical industry will have to
undergo in the 21st century."

Fuels, as well as a variety of polymers, representing a global
market of $29b, can be manufactured from isobutene. Global Bioenergies is now
focused on repeating this success with other molecules of the light olefin
family, such as ethylene and propylene, each one associated with markets
greater than $100b.

www.global-bioenergies.com

Press and public relations:

Benedicte.Robert@global-bioenergies.com - Phone: +33-1-64-98-20-50

Press and public relations: Benedicte.Robert at global-bioenergies.com - Phone: +33-1-64-98-20-50