Interventional Spine(R), Inc. Announces Issuance of Key Patents for the PERPOS(R) PLS System

IRVINE, California, November 4, 2010 - Interventional Spine(R), Inc. today announced that the United States
Patent Office has issued U.S. Patent No. 7,824,429, entitled Method and
Apparatus for Spinal Fixation. This patent includes 43 claims that provide
key patent protection for the Company's percutaneous transfacet-pedicular
compression system for posterior spine fixation sold under the PERPOS(R) PLS
System name and including the Company's BONE-LOK(R) implant. This patent
further strengthens the Company's patent portfolio for its key technologies,
which also includes the patented CLASP(R) (Compression Locking Anchor with
Secondary Purchase) Technology.

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Interventional Spine(R), Inc. is a leading innovator of percutaneous
technologies in the treatment of back pain with over 10,000 patients being
treated to date with the PERPOS(R) PLS System and the BONE-LOK(R) implant.

The PERPOS(R) PLS System is a complete set of instruments engineered for
percutaneous implantation of the BONE-LOK(R) implant, which is a unique
one-size fits all implant that enables single or multi-level bilateral
fixation without rods and screws. The BONE-LOK(R) implant with CLASP(R)
Technology provides higher compression capabilities than standard devices
which can lead to better stability during a fusion procedure of the lower
spine. It also provides intraoperative flexibility for surgeons.

Interventional Spine(R), Inc. is a privately held company based in
Irvine, California, that designs, develops and markets patented implantable
devices for the spine that can be deployed via percutaneous techniques.
Supported by the Company's unique product introduction systems,
Interventional Spine's products provide benefits to patients, surgeons and
hospitals alike. More information on the Company and its products can be
found at: www.i-spineinc.com.

    FOR FURTHER INFORMATION CONTACT:
    Walter A. Cuevas
    Chief Executive Officer
    +1-949-472-0006

Walter A. Cuevas, Chief Executive Officer of Interventional Spine, Inc., +1-949-472-0006