Italy's National Agency for Regional Health Services (Agenas) Names Zimmer(R) NexGen(R) LPS Knee the Most Cost-Effective Total Knee Replacement Implant

By Zimmer Holdings Inc., PRNE
Monday, December 13, 2010

WINTERTHUR, Switzerland, December 14, 2010 - Zimmer Holdings, Inc. (NYSE: ZMH; SIX: ZMH), a leader in musculoskeletal
care, today announced that the Zimmer NexGen LPS knee was ranked the most
cost-effective multiradius design total knee replacement implant in Italy in
a recent health technology assessment by Italy's National Agency for Regional
Health Services.(1)

The assessment identified the prostheses used in Italy for total knee
replacements, examined their performance based on clinical studies and
arthroplasty registers and constructed a cost-effectiveness model to support
buying decisions. The study collected data from 172 public hospitals and
private accredited providers of the Italian National Health Service.
Researchers focused on patients aged 50 and older who had received a primary
implant with a minimum follow-up period of five years.

"Knee replacement surgery is a highly effective treatment that restores
active lives to thousands of patients each year," said Oriol Lacorte, Vice
President Marketing EMEA. "As the world's leading provider of knee implant
technologies, we are proud to receive this recognition for our NexGen LPS
system which has a long history of cost-effective clinical success."

Since its introduction in 1996, Zimmer's NexGen LPS implant has
frequently been used for first-time knee replacement patients. It is a
posterior stabilized implant, intended for patients who have adequate bone
stock with ligaments that provide moderate joint stability or when the
posterior cruciate ligament (PCL) has been cut or removed. The NexGen LPS
system is part of Zimmer's NexGen family of products, one of Zimmer's
best-selling knee brands with over one million knees implanted worldwide
since its introduction. The NexGen knee system is a completely modular
system. Its success is built on multiple technologies such as Prolong(R)
Highly Crosslinked Polyethylene, Trabecular Metal(TM) technology, safe
high-flexion designs up to 155 degrees and anatomical fit for gender-specific

For more information about the NexGen family of products, please visit

About the Company

Founded in 1927 and headquartered in Warsaw, Indiana, Zimmer designs,
develops, manufactures and markets orthopaedic reconstructive, spinal and
trauma devices, dental implants, and related surgical products. Zimmer has
operations in more than 25 countries around the world and sells products in
more than 100 countries. Zimmer's 2009 sales were approximately $4.1 billion.
The Company is supported by the efforts of more than 8,000 employees

For more information about Zimmer, visit

(1) Cerbo M., Fella D, Jefferson T, Migliore A, Paone S, Perrini MR
Velardi L. Agenas HTA Report - Prostheses for primary total knee replacement
in Italy. Rome, July 2009.

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Media: Sabine Ciccotosto, +41(0)52-262-72-41, sabine.ciccotosto at, Investors: Paul Blair, +1-574-371-8042, paul.blair at

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