USDA Approves LISTEX as Processing Aid Against Listeria

By Micreos Food Safety, PRNE
Monday, May 23, 2011

WAGENINGEN, The Netherlands, May 24, 2011 -

The USDA has approved LISTEX as an antimicrobial processing aid to combat
Listeria monocytogenes. Listeria is considered one of the most important food
safety threats, due to its high mortality rate of over 20% and its risk to
pregnant women.

Today's USDA's decision will enable food processing companies to deliver
safer clean label products to the marketplace, without the need for
reformulation or compromise on quality. The approval is in line with Health
Canada's decision last September to approve LISTEX as a processing aid.

LISTEX eliminates Listeria, rather than merely inhibiting its outgrowth.
As such it can be used as an Alternative-2 or as part of an Alternative-1
compliance under the USDA 2003 final rule for post-lethality exposed RTE meat
products. It is certified USDA organic and does not affect the taste, texture
or other organoleptic properties of treated food products. It can therefore
be used for natural as well as organic foods. LISTEX is highly consistent in
eliminating Listeria and easy to apply by topical spraying.

Micreos' CEO Mark Offerhaus: "Consumers and food processors alike will
benefit from the USDA's decision. Phages are abundant in our environment and
foods, but thanks to today's technology we can harness their power and help
prevent unnecessary suffering, economic losses and environmental strain".

The threat from Listeria is real and not to be ignored, Centers for
Disease Control and Prevention (CDC) and USDA emphasize. "About one of five
patients with listeriosis dies," says Benjamin Silk, with CDC's Enteric
Diseases Epidemiology Branch. Listeriosis and cold cuts were ranked as the
third worst combination of a food and a pathogen in terms of the burden they
place on public health, costing $1.1 billion a year in medical costs and lost
work days, according to a study published last April by the University of
Emerging Pathogen Institute.

Despite the increased legal and sanitary measures, the trend in
Listeriosis cases has not seen a downturn. In the United States, the CDC
estimates that 2,500 people become seriously ill with Listeriosis each year,
with several hundred deaths each year. Latest information by the CDC reports
an increase of 19%. This is consistent with the trend in the EU as reported
by EFSA (European Food Safety Authority), confirming Listeria as a major
public health threat.

MICREOS ( formerly: EBI Food Safety, located in
Wageningen ("Food Valley"), The Netherlands, develops and markets phage
products against dangerous pathogens and is viewed as product leader in this
field. The company collaborates with many independent partners and
institutes, including Mississippi State University, the Federal Technology
Institute (ETH) Zurich, Danish Meat Research Institute, NIZO Food Research of
The Netherlands, Nofima of Norway and Ghent University in Belgium. Micreos
Food Safety recently launched a new product against Salmonella, SALMONELEX.

    Quick guide to phages

    - Phages are essential for life on earth, killing roughly half of all
    bacteria every two days

    - They are the most common micro-organisms on our planet, present in
    abundance on our food, skin, in our gut, etc.

    - Phages are harmless to plants and animals (and humans)

    - They are bacteria-specific, enabling targeted bacterial control

    - Phages are approximately 100 times smaller than bacteria and outnumber
    them 10:1

    - Phages are specific for their target bacterial host, and will not
    (a) desired bacteria in foods (e.g., starter cultures)
    (b) commensals ('good bacteria') in our gastro-intestinal tract
    (c) accompanying bacterial flora in the environment

    - Phages are generally composed entirely of proteins and nucleic acids,
    and their eventual breakdown products consist exclusively of amino acids
    and nucleic acids. Thus, they are not xenobiotics and do not leave an
    ecological footprint
    Quick guide to LISTEX

    - LISTEX is winner of FI Europe's "Best Innovation in Food" Gold Award,
    viewed by many as the Oscar of the food industry, awarded every two

    - Many research institutes have demonstrated the efficacy of LISTEX
    against Listeria

    - The phages in LISTEX do not affect "good" bacteria - but are lethal to
    only Listeria, which - despite rigorous cleaning controls - can hide in
    the nooks and crannies of processing equipment, and can be present on
    skin of cattle, in gills of fish, on people, etc.

    - Harmless to humans, high numbers of phages are routinely consumed with
    our food, without any impact on human health or taste or enjoyment of
    the food product

    - Applied during processing, phages can kill the susceptible bacterial
    hosts rapidly without interruption of production

    - LISTEX is an innovative processing aid that does not affect the
    organoleptic properties of the food in any way nor provide any other
    function - indeed the food product's integrity is fully protected and -
    best of all - LISTEX is completely organic and natural.

Micreos Food Safety, Nieuwe Kanaal 7P, 6709 PA, Wageningen, The Netherlands, +31-317-421-414, Info at, Dirk de Meester,
Direct:+31-646-048-503, d.demeester at, Wim Nuboer, Direct: +31-653-322-700, w.nuboer at

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