Study Shows Cardiovascular Deaths in Europe Could Be Prevented

Many at-Risk Patients May not be Receiving the Best Preventative Care

PRAGUE, November 8, 2010 - Cardiovascular disease (CVD) is the leading cause of death in Europe,
killing an estimated 4.3 million people each year.[i] Results from a large
pan-European study announced today indicate that many of these deaths could
be avoided if at-risk patients received better preventative care.[ii]

The European Study on Cardiovascular Risk Prevention and Management in
Daily Practice (EURIKA) estimated the proportion of deaths associated with
risk factors for CVD, and assessed how well those risk factors are managed.
Results confirmed that people with one or more risk factors - such as
smoking, high blood pressure, diabetes, high cholesterol and obesity - have
an increased chance of dying from CVD and, worryingly, that these risk
factors are not being managed effectively in daily clinical practice which
could lead to an excessive number of deaths from CVD.[iii]

The experts behind the study believe that through better identification
and management of these risk factors, a large proportion of coronary deaths
across Europe could be avoided.[ii]

Professor Jean Dallongeville from the Institut Pasteur de
Lille, Lille Cedex, France, one of the experts behind the study, said: "These
results show us just how crucial it is to manage CVD risk factors effectively
- doing so could save thousands of lives across Europe each year, but
unfortunately there is still work to be done. With the EURIKA study findings
we have a better understanding of where the gaps are and what we can do to
reduce the number of avoidable deaths moving forward."

One-third of EURIKA study patients were considered to be at high risk of
fatal cardiovascular disease[ii]

The EURIKA study included 7,641 subjects over the age of 50 who did not
have CVD, but had at least one risk factor for the condition.iii The experts
involved in the study estimated the increased risk of death associated with
each risk factor. They found that smokers had a 17% increased risk of CVD
death, with rates increasing to 23% for those with high blood pressure, 26%
for those with poorly managed cholesterol and 30% for those with diabetes.

Additional findings showed that amongst patients being treated for a risk
factor for CVD, nearly two-thirds (60%) did not have their risk factor
managed to the standards set by European guidelines.

Use of available risk assessment tools and CVD guidelines[iv]

As part of the EURIKA study, 806 doctors were surveyed to understand
their use of risk assessment tools and guidelines and explored factors which
influenced how often they were used.

As many as 30% of doctors said they did not use risk assessment tools at
all and nearly 13% of doctors said they did not follow guidelines on the
management of cardiovascular risk, citing reasons including time constraints,
lack of usefulness and inadequate understanding of risk assessment tools and
guidelines as the key reasons.

Professor Julian Halcox, Cardiff University, UK, another of the experts
behind the study, concluded: "These systems exist to help doctors identify
and manage risk factors well before they become a problem, but we now see
that they are widely under-utilised across Europe. It is vital that doctors
use these tools effectively to assess and communicate risk whenever they
evaluate a patient - in doing so they will help reduce the excessive number
of preventable deaths in Europe each year."

The findings announced today at the International Society For
Pharmacoeconomics and Outcomes Research (ISPOR) annual meeting are the first
results from the study. Further data, including a country-by-country
breakdown of results, are expected in 2011. The EURIKA study was funded by
AstraZeneca as part of its ongoing commitment to improving the management of
CVD and its risk factors. The study was designed, executed and analysed by an
independent panel of academic experts from across Europe.

About the EURIKA Study

The European Study on Cardiovascular Risk Prevention and
Management in Daily Practice (EURIKA) was a large public health study funded
by AstraZeneca to assess the level of control of the main risk factors which
can lead to CVD. The EURIKA study was conducted across 12 European countries
including Austria, Belgium, France, Germany, Greece, Norway, Russia, Spain,
Sweden, Switzerland, Turkey and the UK. These countries were selected to
represent the whole spectrum of CVD risk, risk factor control, and
organisation of health-care services across Europe. Data collection started
in May 2009 and was completed in January 2010.

About the EURIKA Study Steering Committee

The EURIKA study was designed, executed and analysed by an
independent academic Steering Committee, comprising experts from across
Europe. Members of the Steering Committee included:

    - Jean Dallongeville, Inserm U 744, Institut Pasteur de Lille, Lille
      Cedex, France.

    - Jose R. Banegas, Department of Preventative Medicine and Public Health.
      School of Medicine, Universidad Autonoma de Madrid. CIBER of
      Epidemiology and Public Health. Madrid, Spain

    - Fernando Rodriguez Artalejo, Department of Preventative Medicine and
      Public Health. School of Medicine, Universidad Autonoma de Madrid.
      CIBER of Epidemiology and Public Health. Madrid, Spain

    - Eliseo Guallar, Departments of Epidemiology and Medicine and Welch
      Center for Prevention, Epidemiology, and Clinical Research. John
      Hopkins Bloomberg School of Public Health. Baltimore, USA; Department
      of Cardiovascular Epidemiology and Population Genetics. National
      Center for Cardiovascular Research (CNIC). Madrid, Spain.

    - Claudio Borghi, Department of Internal Medicine, Ageing and Clinical
      Nephrology. University of Bologna, Bologna, Italy.

    - Guy De Backer , Professor Emeritus, Ghent University. Past-chair of the
      Department of Public Health, Ghent University, Ghent Belgium. Past
      -director of the Dept of Cardiology at Ghent University Hospital Ghent
      Belgium.

    - Julian P.J. Halcox, Wales Heart Research Institute, Cardiff University,
      Cardiff, UK.

    - Joep Perk, School of Health and Caring Sciences, Linnaeus University,
      Kalmar, Sweden.

    - Ph.Gabriel Steg, INSERM U-698, Universite Paris-Diderot and Assistance
      Publique - Hopitaux de Paris, Paris, France

About AstraZeneca

AstraZeneca is a global, innovation-driven biopharmaceutical business
with a primary focus on the discovery, development and commercialisation of
prescription medicines. As a leader in gastrointestinal, cardiovascular,
neuroscience, respiratory and inflammation, oncology and infectious disease
medicines, AstraZeneca generated global revenues of US $32.8 billion in 2009.
For more information please visit: www.astrazeneca.com

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[i] European Heart Network. Cardiovascular Disease Statistics.
www.ehnheart.org/cdv-statistics.html

Accessed on 22 October 2010.

[ii] Banegas J, et al. Prevalence and control of traditional
cardiovascular risk factors and anticipated avoidable coronary mortality in
primary prevention in Europe: The EURIKA Study. PCV30. Presented at the ISPOR
13th Annual European Congress, 6-9 Nov 2010, Prague, Czech Republic

[iii] Rodiguez-Artalejo F, et al. BMC Public Health. 2010; 10:382

[iv] Dallongeville J, et al. A survey of physicians' attitudes towards
the control of cardiovascular risk factors. The EURIKA Study. PCV121.
Presented at the ISPOR 13th Annual European Congress, 6-9 Nov 2010, Prague,
Czech Republic

For more information about the EURIKA study, or to speak with
one of the experts involved in the study, please contact: Hayley Raffill, Porter Novelli +44(0)20-7853-2227, hayley.raffill at porternovelli.co.uk; Sarah Schapira, Porter Novelli, +44(0)20-7853-2228, sarah.schapira at porternovelli.co.uk; Harry King, Porter Novelli, +44(0)20-7853-2276, harry.king at porternovelli.co.uk