Shire Receives LIALDA(R) Paragraph IV Notice Letter From Zydus Pharmaceuticals

DUBLIN, May 28, 2010 - Shire plc (LSE: SHP, NASDAQ: SHPGY), the global specialty
biopharmaceutical company, announces that it has received a Paragraph IV
Notice Letter today from Zydus Pharmaceuticals USA, Inc. ("Zydus") advising
of the filing of an Abbreviated New Drug Application ("ANDA") for a generic
version of Shire's 1.2g mesalamine delayed release tablets, LIALDA(R).

LIALDA is protected by the following FDA Orange Book listed patent: U.S.
Patent No. 6,773,720, Mesalazine Controlled Release Pharmaceutical
Compositions (the "'720 patent"). The patent expires in 2020.

Shire is currently reviewing the details of Zydus' Paragraph IV Notice
Letter. Under the Hatch-Waxman Act, Shire has 45 days from the receipt of the
Notice Letter to determine if it will file a patent infringement suit. If
Shire brings suit pursuant to the Hatch Waxman regulations, a stay of
approval of up to 30-months will be imposed by the FDA on Zydus' ANDA.

Notes to Editors

SHIRE PLC

Shire's strategic goal is to become the leading specialty
biopharmaceutical company that focuses on meeting the needs of the specialist
physician. Shire focuses its business on attention deficit hyperactivity
disorder (ADHD), human genetic therapies (HGT) and gastrointestinal (GI)
diseases as well as opportunities in other therapeutic areas to the extent
they arise through acquisitions. Shire's in-licensing, merger and acquisition
efforts are focused on products in specialist markets with strong
intellectual property protection and global rights. Shire believes that a
carefully selected and balanced portfolio of products with strategically
aligned and relatively small-scale sales forces will deliver strong results.

For further information on Shire, please visit the Company's website:
www.shire.com.

"SAFE HARBOR" STATEMENT UNDER THE PRIVATE SECURITIES LITIGATION REFORM
ACT OF 1995

Statements included herein that are not historical facts are
forward-looking statements. Such forward-looking statements involve a number
of risks and uncertainties and are subject to change at any time. In the
event such risks or uncertainties materialize, the Company's results could be
materially affected. The risks and uncertainties include, but are not limited
to, risks associated with: the inherent uncertainty of pharmaceutical
research, product development, manufacturing and commercialization including,
but not limited to, the establishment in the market of VYVANSE(TM)
(lisdexamfetamine dimesylate) (Attention Deficit Hyperactivity Disorder
("ADHD")); the impact of competitive products, including, but not limited to,
the impact of those on the Company's ADHD franchise; patents, including but
not limited to, legal challenges relating to the Company's ADHD franchise;
government regulation and approval, including but not limited to the expected
product approval date of INTUNIV(TM) (guanfacine extended release) (ADHD);
the Company's ability to secure new products for commercialization and/or
development; the Company's proposed offer for Jerini AG, including but not
limited to, the Company's ability to successfully complete the offer and
integrate Jerini AG, as well as realize the anticipated benefits of the
acquisition; and other risks and uncertainties detailed from time to time in
the Company's filings with the Securities and Exchange Commission, including
the Company's Annual Report on Form 10-K for the year ended December 31,
2007.

    For further information please contact:

    Investor Relations Clea Rosenfeld (Rest of the World) +44-1256-894-160
                       Eric Rojas (North America)         +1-781-482-0999

    Media              Jessica Mann (Rest of the World)   +44-1256-894-280
                       Matthew Cabrey (North America)     +1-484-595-8248

For further information please contact: Investor Relations - Clea Rosenfeld (Rest of the World), +44-1256-894-160, Eric Rojas (North America), +1-781-482-0999 ; Media - Jessica Mann (Rest of the World), +44-1256-894-280, Matthew Cabrey (North America), +1-484-595-8248