Second Quarter 2010 Results Date Notification - August 4, 2010

DUBLIN, July 15, 2010 - Shire plc (LSE: SHP, NASDAQ: SHPGY), the global specialty
biopharmaceutical company, will announce second quarter 2010 earnings on
Wednesday August 4, 2010.

    Results press release will be issued at:     12:00 BST / 07:00 EDT
    Investor conference call time:               14:00 BST / 09:00 EDT

Live conference call for investors:

Angus Russell, Chief Executive Officer and Graham Hetherington, Chief
Financial Officer will host the investor and analyst conference call at 14:00
BST/9:00 EDT.

The details of the conference call are as follows:

    UK dial in:                 0844-800-3850 or 01296-480-180
    US dial in:                 1-866-8048688 or 1-718-3541175
    International dial in:      01296-480-180
    Password/Conf ID:           523007
    Live Webcast:               www.shire.com/shireplc/en/investors

Replay:

A replay of the presentation will be available for two weeks by phone and
by webcast for one year. Details can be found on our Investor Relations
website www.shire.com/shireplc/en/investors.

Notes to editors

SHIRE PLC

Shire's strategic goal is to become the leading specialty
biopharmaceutical company that focuses on meeting the needs of the specialist
physician. Shire focuses its business on attention deficit hyperactivity
disorder (ADHD), human genetic therapies (HGT) and gastrointestinal (GI)
diseases as well as opportunities in other therapeutic areas to the extent
they arise through acquisitions. Shire's in-licensing, merger and acquisition
efforts are focused on products in specialist markets with strong
intellectual property protection and global rights. Shire believes that a
carefully selected and balanced portfolio of products with strategically
aligned and relatively small-scale sales forces will deliver strong results.

For further information on Shire, please visit the Company's website:
www.shire.com.

    For further information please contact:

    Investor Relations: Souheil Salah (Rest of the World), +44-1256-894-160
                        Ricki Greenwood (North America),   +1-484-595-8517

For further information please contact: Investor Relations: Souheil Salah (Rest of the World), +44-1256-894-160 ; Ricki Greenwood (North America), +1-484-595-8517.